王銳，男，漢族。第十四屆全國政協常委，中國工程院院士（醫藥衛生學部），中國醫學科學院學術咨詢委員會學部委員，中國醫學科學院藥物研究所執行所長，北京協和醫學院特聘教授，蘭州大學萃英學者一級教授，中國藥學會副理事長，中華醫學會常務理事，國家藥典委員會執行委員，教育部“多肽藥物”創新團隊負責人，教育部長江學者特聘教授，國家萬人計劃領軍人才，國家杰出青年科學基金獲得者。1978年考入蘭州大學，1988年獲博士學位（蘭州大學與日本京都大學聯合培養），蘭州大學博士后，美國University of Kansas博士后，香港理工大學教授。曾任蘭州大學副校長、醫學部主任、基礎醫學院院長、生命科學學院創院院長、甘肅省科協副主席，第十二屆全國政協委員、第十三屆全國政協常委。
      院校引進人才，2021年加入院校。

王銳院士率領團隊長期圍繞制約多肽新藥創制的關鍵科學和技術問題，進行了系統的創新性研究，取得了突出成就，為我國多肽新藥創制及產業化的發展做出了重要貢獻。作為第一完成人獲國家自然科學獎二等獎和國家技術發明獎二等獎各1項、教育部科技一等獎2項、甘肅省科技一等獎2項、國際學術獎勵3項、獲何梁何利科技獎。以通訊作者發表SCI論文500余篇，論文被引用2萬余次，連續九年入選Elsevier“中國高被引學者”。獲國家發明專利授權和美國、歐盟及日本授權發明專利80余件，多項專利技術用于多肽新藥研發與生產，獲中國專利獎。通過產學研合作研發的若干創新藥正在進行臨床試驗。為我國培養了一大批德才兼備的優秀人才。

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1．Kun Wang#，Ke Wang#，Cong Wang，Hange Yang，Gangzhong Zhou，Peihong Ji，Xudong Sun，Gong Chen，Xuegong Fan，Kuan Hu*，Juan Yi*, Hailong Zhang* and Rui Wang*. Development of Dual-Receptor Lysosome-Targeting Chimeras for Protein Degradation. Journal of the American Chemical Society. 2025. https://doi.org/10.1021/jacs.5c13695. (IF=15.6).

2．Kun Wang#, Cong Wang#, Hange Yang#, Gong Chen#, Ke Wang, Peihong Ji, Xudong Sun, Xuegong Fan, Jie Ma, Zhencun Cui, Xingkai Wang, Hao Tian, Dengfu Wu, Lu Wang, Zhimin Wang, Jiangyan Liu, Juan Yi*, Kuan Hu*, Hailong Zhang*, Rui Wang*. A dual-targeting peptide–drug conjugate based on CXCR4 and FOLR1 inhibits triple-negative breast cancer. Acta Pharmaceutica Sinica B. 2025. 15 (10): 4995-5009 (IF=14.6).

3．Ruixuan Wang#, Siqi Ran#, Jiabei Guo#, Da Hu#, Xiang Feng, Jixia zhou, Zhanzhi Zhang, Futian Liang, Jiamin Shang, Lingxin Bu, Kaiyi Wang, Junyi Mao, Huixin Luo*, Rui Wang*. mRNA display-enabled discovery of proximity-triggered covalent peptide–drug conjugates. Acta Pharmaceutica Sinica B. 2025. 15 (10): 5474-5485 (IF=14.6).

4．Quan Zuo#, Xinyi Song#, Jie Yan#, Guangjun Bao, Yiping Li, Jieting Shen, Zeyuan He, Kuan Hu*, Wangsheng Sun*, Rui Wang*. Triazination/IEDDA Cascade Modular Strategy Installing Pyridines/Pyrimidines onto Tyrosine Enables Peptide Screening and Optimization. Journal of the American Chemical Society. 2025. 147 (11): 9576–9589 (IF=15.6).

5．Siqi Zhang, Xingkai Wang, Xin Gao, Xueyao Chen, Linger Li, Guoqing Li, Can Liu, Yuan Miao, Rui Wang*, Kuan Hu*. Radiopharmaceuticals and their applications in medicine. Signal Transduction and Targeted Therapy. 2025. 10, 1. (IF=52.7).

6．Zhen Shan, Jian-Ze Xiao, Miaomiao Wu, Jinjian Wang, Jian Su, Ming-Shui Yao*, Ming Lu, Rui Wang*, Gen Zhang*. Topologically Tunable Conjugated Metal–Organic Frameworks for Modulating Conductivity and Chemiresistive Properties for NH3 Sensing. Angewandte Chemie-International Edition. 2024. 63 (16): e202401679 (IF=16.9).

7．Quan Zuo, Yiping Li, Xuanliang Lai, Guangjun Bao, Lu Chen, Zeyuan He, Xinyi Song, Ruiyao E, Pengxin Wang, Yuntao Shi, Huixin Luo, Wangsheng Sun*, Rui Wang*. Cysteine-specific Multifaceted Bioconjugation of Peptides and Proteins Using 5-Substituted 1,2,3-Triazines. Advanced Science. 2024. 11 (21): 2308491 (IF=15.1).

8．Guangjun Bao, Xinyi Song, Yiping Li, Zeyuan He, Quan Zuo, Ruiyao E, Tingli Yu, Kai Li, Junqiu Xie*, Wangsheng Sun*, Rui Wang*. Orthogonal bioconjugation targeting cysteine-containing peptides and proteins using alkyl thianthrenium salts. Nature Communications. 2024. 15, 6909 (IF=15.7).

9．Hange Yang*, Xiaowei Zhang*, Cong Wang*, Hailong Zhang*#, Juan Yi, Kun Wang, Yanzhe Hou, Peihong Ji, Xiaojie Jin, Chenghao Li, Min Zhang, Shan Huang, Haoyuan Jia, Kuan Hu, Lingyun Mou*, Rui Wang*. Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β. Signal Transduction and Targeted Therapy. 2023. 8(1):428 (IF=40.8).

10．Tongtong Liu, Yayun Zhang, Zhen Shan, Miaomiao Wu, Bocong Li, Hao Sun, Guanyong Su*, Rui Wang*, Gen Zhang*. Covalent organic framework membrane for efficient removal of emerging trace organic contaminants from water. Nature Water. 2023. 1, 1059–1067 (IF=20.1).