石建功,1964年生,籍貫甘肅渭源,天然藥物化學(xué)專家,藥物研究所研究員,博士生導(dǎo)師。1981年考入蘭州醫(yī)學(xué)院藥學(xué)專業(yè),1985年獲學(xué)士學(xué)位。1987年在蘭州醫(yī)學(xué)院藥學(xué)專業(yè)攻讀碩士學(xué)位,從事中草藥化學(xué)成分研究。1990年在蘭州大學(xué)化學(xué)專業(yè)攻讀博士學(xué)位,從事天然有機化學(xué)研究。作為博士后,先后于1993年在中國科學(xué)院蘭州化學(xué)物理研究所、1995年在美國Illinois大學(xué)化學(xué)系、1997年在Puerto Rico大學(xué)化學(xué)系,開展天然產(chǎn)物化學(xué)研究。1998年獲聘副研究員,1999年起任研究員。
常用中藥化學(xué)成分及其生物活性研究。重點開展常用中藥多樣性成分的系統(tǒng)分離、結(jié)構(gòu)鑒定及其與藥理學(xué)緊密結(jié)合的多模型藥理活性篩選和評價,以及活性化合物的結(jié)構(gòu)優(yōu)化和合成研究。
1.Jingfang Zhang#, Xiaoqiang Lei, Yazi Wei, Hui Liu, Qinglan Guo*, Tiantai Zhang*, and Jiangong Shi*. Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii. Chin. Chem. Lett. 33(12):5047–50. (IF=8.455)
2. Xiaoqiang Lei#*, Juan Feng, Qinglan Guo, Chengbo Xu, and Jiangong Shi*. Base-promoted formal [3 + 2] cycloaddition of α?halohydroxamates with carbon disulfide to synthesize polysubstituted rhodanines. Org. Lett. 24(15):2837–41. (IF=6.579)
3. Youzhe Chen#, Qinglan Guo, Chengbo Xu, Chenggen Zhu, Jianjun Zhang*, and Jiangong Shi*. (+)-/(?)-Angelignanine, a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head. Chin. Chem. Lett. 32(5):1657?9. (IF=8.455)
4. Qinglan Guo#, Huan Xia#, Yuzhuo Wu, Shuai Shao, Chengbo Xu, Tiantai Zhang*, and Jiangong Shi*. Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from Aconitum carmichaelii. Acta Pharm. Sin. B 10(10):1954?65. (IF=11.614)
5. Qinglan Guo#, Dawei Li, Chengbo Xu, Chenggen Zhu, Ying Guo, Haibo Yu, Xiaoliang Wang, and Jiangong Shi*. Indole alkaloid glycosides with a 1?-(phenyl)ethyl unit from Isatis indigotica leaves. Acta Pharm. Sin. B 10(5):895?902. (IF=11.614)
6. Yuzhuo Wu#, Shuai Shao#, Qinglan Guo, Chengbo Xu, Huan Xia, Tiantai Zhang*, and Jiangong Shi*. Aconicatisulfonines A and B, analgesic zwitterionic C20-diterpenoid alkaloids with a rearranged atisane skeleton from Aconitum carmichaelii. Org. Lett. 21(17):6850–4. (IF=6.091)
7. Minghua Chen#, Lishe Gan, Sheng Lin, Xiaoliang Wang, Li Li, Yuhuan Li, Chenggen Zhu, Yanan Wang, Bingya Jiang, Jiandong Jiang, Yongchun Yang, and Jiangong Shi*. Alkaloids from the root of Isatis indigotica. J. Nat. Prod. 75(6):1167–76. (IF=3.285)
8. Liang Xiong#, Chenggeng Zhu*, Yanru Li, Ye Tian, Sheng Lin, Shaopeng Yuan, Jinfeng Hu, Qi Hou, Naihong Chen, Yongchun Yang, and Jiangong Shi*. Lignans and neolignans from Sinocalamus affinis and their absolute configurations. J. Nat. Prod. 74(5):1188–200. (IF=3.128, C100)
9. Maoluo Gan#, Yanling Zhang, Sheng Lin, Mingtao Liu, Weixia Song, Jiachen Zi, Yongchun Yang, Xiaona Fan, Jiangong Shi*, Jinfeng Hu, Jiandong Sun, and Naihong Chen*. Glycosides from the root of Iodes cirrhosa. J. Nat. Prod. 71(4):647–54. (IF=2.843, C100)
10. Shunyan Mo#, Sujuan Wang, Guangxiong Zhou, Yongchun Yang, Yan Li, Xiaoguang Chen, and Jiangong Shi*. Phelligridins C?F: Cytotoxic pyrano[4,3-c][2]benzopyran-1, 6-dione and furo[3,2-c] pyran-4-one derivatives from the fungus Phellinus igniarius. J. Nat. Prod. 67(5):823–8. (IF=2.202, C100)