李貴登，中國醫學科學院系統醫學研究院研究員/蘇州系統醫學研究所研究員。國家自然基金青年科學基金項目（A類），海外高層次青年人才項目和江蘇省“杰出青年基金項目”獲得者。入選江蘇省雙創人才和江蘇省“333工程”中青年科技領軍人才。曾于加州理工學院諾貝爾獎獲得者David Baltimore實驗室完成博士后訓練，多年來聚焦于腫瘤T細胞免疫的分子機理研究，開發新型腫瘤免疫治療技術和方法。
      院校引進人才，2019年加入院校。

專注探究腫瘤T細胞免疫的分子機理研究，開發新型腫瘤免疫治療技術和方法。以通訊作者（含共同）在Cancer Cell (2篇)、Immunity、Nature Metabolism、Nature Methods、Nature Communications 、Blood、Advanced Science和Cell Reports等國際權威期刊發表論文10 余篇，為Nature Reviews Immunology、Nature Methods (2篇)和Cell Metabolism (2篇)等期刊撰寫綜述和評論。承擔國家自然科學基金項目、國家科技創新2030重大項目以及醫科院創新工程和基礎等科研項目10余項。擔任中國免疫學會理事會理事和中國免疫學會腫瘤免疫與生物治療分會委員等職務。

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1. Kaili Ma#, Hongcheng Cheng#, Lin Wang#, Han Xiao#, Fenghua Liu#, Yu Yang, Zhen Xiao, Kun Tang, Shicheng Li, Gang Wang, Minmin Ge, Jiajia Wang, Xiaowei Liu, Hai-Xi Sun, Ziyi Luo, Zhimin Gu*, Ping-Chih Ho*, Guideng Li*, Lianjun Zhang*. Succinate preserves CD8+ T cell fitness to augment antitumor immunity. Immunity. 2025; 58(10): 2505-2523.e8. (IF=33.2)

2. Shanshan Zhang#, Yan Zhou#, Zhonghua Liu#, Yuqian Wang#, Xiang Zhou, Haiwen Chen, Xinyu Zhang, Yanhong Chen, Qisheng Feng, Xiaoping Ye, Shanghang Xie, Musheng Zeng, Weiwei Zhai, Yixin Zeng*, Sumei Cao*, Guideng Li*, Miao Xu*. Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma. Cancer Cell. 2025; 43(8): p1423-1441.e10. (IF=47.2, ESI)

3. Yajing Qiu#, Yapeng Su#, Ermei Xie#, Hongcheng Cheng#, Jing Du#, Yue Xu, Xiaoli Pan, Zhe Wang, Daniel G. Chen, Hong Zhu, Philip D. Greenberg*, Guideng Li*. Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity. Cancer Cell. 2025; 43(1): 103–121.e8. (IF=47.2)

4. Yuqian Wang#, Zhe Wang#, Juan Yang#, Xiaobo Lei, Yisu Liu, Luke Frankiw, Jianwei Wang*, Guideng Li*. Deciphering membrane-protein interactions and high-throughput antigen identification with cell doublets. Advanced Science. 2024; 11(13): e2305750. (IF=15.6)

5. Zhe Wang#, Jingzhe Shang#, Yajing Qiu#, Hongcheng Cheng, Mengyuan Tao, Ermei Xie, Xin Pei, Wenhui Li, Lianjun Zhang*, Aiping Wu*, Guideng Li*. Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity. Cell Reports. 2024; 43(2): 113796. (IF=8.1)

6. Yisu Liu#, Yuqian Wang#, Zhiqiang Peng, Guideng Li*, Jianwei Wang*. T cell cross-reactivity in autoimmune-like hepatitis triggered by COVID-19. hLife. 2023; 1(1): 57–61. (暫無影響因子數據)

7. Hongcheng Cheng#, Yajing Qiu#, Yue Xu#, Li Chen#, Kaili Ma, Mengyuan Tao, Luke Frankiw, Hongli Yin, Ermei Xie, Xiaoli Pan, Jing Du, Zhe Wang, Wenjie Zhu, Lu Chen*, Lianjun Zhang*, Guideng Li*. Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness. Nature Metabolism. 2023; 5(2): 314–330. (IF=21.2, ESI) 

8. Yapeng Su#, Melissa E. Ko#, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, Jihoon W. Lee, Luke Frankiw, Alexander Xu, Stephanie Wong, Lidia Robert, Kaitlyn Takata, Dan Yuan, Yue Lu, Sui Huang, Antoni Ribas, Raphael Levine, Garry P. Nolan, Wei Wei, Sylvia K. Plevritis, Guideng Li*, David Baltimore*, James R. Heath*. Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line. Nature Communications. 2020; 11(1): 2345. (IF=12.121, C100)

9. Guideng Li*#, Michael T. Bethune*#, Stephanie Wong, Alokv Joglekar, Michael T. Leonard, Jessica K. Wang, Jocelyn T. Kim, Donghui Cheng, Songming Peng, Jesse M. Zaretsky, Yichen Su, Yicheng Luo, James R. Heath, Antoni Ribas, Owen N. Witte, David Baltimore*. T cell antigen discovery via trogocytosis. Nature Methods. 2019; 16(2): 183–190. (IF=28.467, C100)

10. Guideng Li*#, Alex Yick-Lun So, Reeshelle Sookram, Stephanie Wong, Jessica K. Wang, Yong Ouyang, Peng He, Yapeng Su, Rafael Casellas, David Baltimore*. Epigenetic silencing of miR-125b is required for normal B-cell development. Blood. 2018; 131(17): 1920–1930. (IF=16.562)