張曉輝，中國醫學科學院系統醫學研究院研究員，北京協和醫學院博士生導師，助理教授。江蘇省雙創人才，姑蘇創新領軍人才。主要從事面向遺傳病治療的堿基編輯技術研究，包括基因編輯工具的開發、優化以及在疾病動物模型和基因治療方面的應用。獲得國家自然科學基金青年科學基金項目（B類和C類）以及國家重點研發計劃等項目資助。
      院校引進人才，2022年加入院校。曾于2020年博士畢業后受聘華東師范大學生命科學學院副研究員，從事基因編輯工具的開發、優化以及在疾病動物模型和基因治療方面的應用。

60%左右遺傳病是基因點突變所致。新一代基因編輯技術-堿基編輯技術，以優于傳統技術的效率與安全性，成為糾正致病點突變的最佳工具。課題組長期從事堿基編輯技術研究，包括基因編輯工具的開發、優化以及在疾病動物模型和基因治療方面的應用。
     近期取得如下進展：1)率先創建雙功能堿基編輯器，突破底物單一限制；2）創建高效、靶向范圍廣的系列新型堿基編輯器，突破效率和靶向范圍限制；3）創建多款高精準堿基編輯器，解決精度不足和脫靶風險；并證明這些新型堿基編輯器在β-地貧治療、動物模型制作等具有廣泛應用前景。相關研究成果以第一/通訊作者在Nature Biotechnology, Nature Cell Biology, Nature Chemical Biology和Nature Communications等學術期刊上發表論文20余篇，授權專利12項。

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1. Jingxuan Ren#, Jiawei Yao#, Qiuyu Cao#, Yinuo Li#, Yang Li#, Ziyi Zhang, Xiyu Ge, Shengfang Wang, Yang Zhang*, Xiaogang Wang*, Xiaohui Zhang*, Protein-nucleic acid language model-assisted design of precise and compact adenine base editor. Nature Communication, DOl:10.1038/s41467-025-65311-z3.(2025). (IF=15.7)

2. Mengyu Shang#, Yinuo Li#, Qiuyu Cao#, Jingxuan Ren#, Yuqiang Zeng, Jinxin Wang, Rachel V. L. Gonzalez, Xiaohui Zhang*. A motif preferred adenine base editor with minimal bystander and off-targets editing. Nature Communications 16, 9153 (2025). (IF=15.7)

3. Niannian Xue#, Xu Liu#, Dan Zhang#, Youming Wu#, Yi Zhong, Jinxin Wang, Wenjing Fan, Haixia Jiang, Biyun Zhu, Xiyu Ge, Rachel V L Gonzalez, Liang Chen, Shun Zhang, Peilu She, Zhilin Zhong, Jianjian Sun, Xi Chen, Liren Wang, Zhimin Gu, Ping Zhu, Mingyao Liu, Dali Li*, Tao P Zhong*, Xiaohui Zhang*. Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD. Nature Communications 14, 1224 (2023). (IF=14.7)

4. Liang Chen#, Shun Zhang#, Niannian Xue#, Mengjia Hong#, Xiaohui Zhang#, Dan Zhang, Jing Yang, Sijia Bai, Yifan Huang, Haowei Meng, Hao Wu, Changming Luan, Biyun Zhu, Gaomeng Ru, Hongyi Gao, Liping Zhong, Meizhen Liu, Mingyao Liu, Yiyun Cheng, Chengqi Yi, Liren Wang, Yongxiang Zhao*, Gaojie Song*, Dali Li*. Engineering a precise adenine base editor with minimal bystander editing. Nature Chemical Biology 19, 101–110 (2022) (IF=14.8)

5. Xiaohui Zhang#, Biyun Zhu#, Liang Chen#, Ling Xie, Weishi Yu, Ying Wang, Linxi Li, Shuming Yin, Lei Yang, Handan Hu, Honghui Han, Yongmei Li, Liren Wang, Geng Chen, Xueyun Ma, Hongquan Geng, Wanfeng Huang, Xiufeng Pang, Zuozhen Yang, Yuxuan Wu, Stefan Siwko, Ryo Kurita, Yukio Nakamura, Li Yang, Mingyao Liu, Dali Li*. A Dual base editor catalyzes both cytosine and adenine base conversions in human cells. Nature Biotechnology 38, 856–860 (2020). (Highlighted by Nature Reviews Genetics). (IF=37, ESI 1%, C100)

6. Xiaohui Zhang#, Liang Chen#, Biyun Zhu#, Liren Wang, Caiyu Chen, Mengjia Hong, Yifan Huang, Huiying Li, Honghui Han, Bailian Cai, Weishi Yu, Shuming Yin, Lei Yang, Zuozhen Yang, Meizhen Liu, Ying Zhang, Zhiyong Mao, Yuxuan Wu, Mingyao Liu, Dali Li*. Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain. Nature Cell Biology 22, 740–750 (2020) (Highlighted by Nature Cell Biology). (IF=28, ESI 1%, C100)

7. Lei Yang#, Xiaohui Zhang#, Liren Wang#, Shuming Yin#, Biyun Zhu, Ling Xie, Qiuhui Duan, Huiqiong Hu, Rui Zheng, Yu Wei, Liangyue Peng, Honghui Han, Jiqin Zhang, Wenjuan Qiu, Hongquan Geng, Stefan Siwko, Xueli Zhang, Mingyao Liu, Dali Li*. Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants. Protein & Cell 9, 814-819 (2018) (Cover story, Highlight by Protein & Cell). (IF=12.8)

8. Xiaohui Zhang#, Liren Wang#, Mingyao Liu* and Dali Li*. CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy. Science China Life Science 60(5):468-475 (2017). (IF=9.5)

9. Xiaohui Zhang#, Louis Y Tee, Xiaogang Wang, Qunshan Huang and Shihua Yang*. Off-target effects in CRISPR/Cas9-mediated genome engineering. Molecular Therapy-Nucleic Acids 4, e264 (2015). (IF=5.0, ESI 1%, C100)