程輝，中國醫學科學院血液病醫院（血研所）研究員，協和準長聘助理教授，博導。2007年獲浙江大學學士學位。2013年獲北京協和醫學院博士學位。研究方向為造血干細胞及其微環境。以第一/通訊作者（含共同）在Nat Cell Biol、J Clin Invest、J Exp Med、Blood等雜志上發表論文和綜述20余篇。國家重點研發計劃首席科學家。獲國家優青、天津市杰青等人才項目。獲國家自然科學獎二等獎。獲國內外專利5項。中國生理學會青年委員和天津市血液與再生醫學學會理事。

作為最早被應用于臨床的成體干細胞，造血干細胞（HSC）功能和分化模式一直以來是研究的熱點。我們實驗室的研究目標是明確HSC在穩態和疾病狀態下的內外調控機制，揭示微環境在其中的變化規律繼而對HSC的影響機理，探討HSC選擇性保護的分子機制，以期為白血病的治療提供新的思路和策略。

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1. Yang S.#, Sun G.#, Wu P.#, Chen C.#, Kuang Y., Liu L., Zheng Z., He Y., Gu Q., Lu T., Zhu C., Wang F., Gou F., Yang Z., Zhao X., Yuan S., Yang L., Lu S., Li Y., Lv X., Dong F., Ma Y., Yu J., Ng L., Shi L., Liu J.*, Shi L.*, Cheng T.*, Cheng H.*. WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation. J Exp Med. 2022; 219(4). (IF= 17.579)

2. Wang T.#, Xia C.#, Weng Q., Wang K., Dong Y., Hao S., Dong F., Liu X., Liu L., Geng Y., Guan Y., Du J., Cheng T., Cheng H.*, Wang J*. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica. 2022; 107(1). (IF=11.047)

3. Wang FJ.#, He J.#, Liu S.#, Gao A., Yang L., Sun G., Ding W., Li C., Wang F., Wang X., Zhu P., Hao S., Ma Y.*, Cheng H.*, Yu J.*, Cheng T*. Comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation. Blood. 2021;138(20). (IF=25.476)

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6. Zhang C.#, Xu Z.#, Yang S.#, Sun G.#, Jia L., Zheng Z., Gu Q., Tao W.*, Cheng T.*, Li C.* and Cheng H.*. tagHi-C reveals 3D chromatin architecture dynamics during hematopoiesis. Cell Rep. 2020;32(13). (IF=9.423)

7.   Dong F., Cheng H.*, Ema H.*, Cheng T*. Probing the fate of transplanted hematopoietic stem cells: is the combinational approach "FIT" for purpose? Sci China Life Sci. 2020;63(11):1755-8. (IF=6.037)

8.   Dong F.#, Hao S.#, Zhang S.#, Zhu C.#, Cheng H.#, et al. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis. Nat Cell Biol. 2020;22(6):630-9. (IF=28.824)

9.   Xia C.#, Wang T.#, Cheng H.#, et al. Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia. 2020;34(9):2375-83. (IF=11.528)

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