張赟,1986年出生,中國(guó)醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院研究員,博士生導(dǎo)師。2004年考入北京大學(xué)生命科學(xué)學(xué)院,2008年獲得學(xué)士學(xué)位。之后在美國(guó)杜克大學(xué)王小凡教授指導(dǎo)下獲博士學(xué)位。在美國(guó)麻省理工學(xué)院懷特海德研究所Robert A. Weinberg教授實(shí)驗(yàn)室進(jìn)行博士后研究,主要從事腫瘤微環(huán)境和腫瘤轉(zhuǎn)移分子機(jī)制的研究。
      院校引進(jìn)人才,2023年加入院校。獲國(guó)家海外高層次人才計(jì)劃青年項(xiàng)目支持。
1.Lambert, A.W.#, Zhang, Y.#, Weinberg, R.A. (2024) Cell-intrinsic and microenvironmental determinants of metastatic colonization. Nat. Cell Biol. 26, 687–697. (IF = 28.213)
2.Li, L., Zhu, R., Zhou, H., Cui, C.‐P., Yu X., Liu, Y., Yin, Y., Li, Y., Feng, R., Katz, J. P., Zhao, Y. Zhang, Y.*, Zhang, L.*, Liu, Z.* (2023) All‐Trans Retinoic Acid Promotes a Tumor Suppressive OTUD6B‐β‐TrCP‐SNAIL Axis in Esophageal Squamous Cell Carcinoma and Enhances Immunotherapy. Adv. Sci. 10(16):e2207458. (IF = 17.521)
3.Zhang, Y.*, Donaher, J. L., Das, S., Li, X., Reinhardt, F., Krall, J. A., Lambert, A., Thiru, P., Keys, H. R., Khan, M., Hofree., M., Wilson, M. M., Yedier-Bayra, O., Lack, N.A., Onder, T. T., Bagci-Onder, T., Tyler, M., Tirosh, I., Regev, A., Lees, J., Weinberg, R.A.* (2022) Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Nat. Cell Biol. 24(4):554-564. (IF = 28.213, C100)
4.Zhang, Y.*, Wang, X. -F.* (2022) 腫瘤微環(huán)境調(diào)控癌癥發(fā)生發(fā)展的研究概述. Microenvironmental regulation of tumor initiation and development (in Chinese). SCIENTIA SINICA Vitae (中國(guó)科學(xué): 生命科學(xué)), 52: 1377-1390. (IF = 1.237)
5.Wang, E., Xiang, K., Zhang, Y.*, Wang, X. -F.* (2022) Patient-derived organoids (PDOs) and PDO-derived xenografts (PDOXs): New opportunities in establishing faithful pre-clinical cancer models, Journal of the National Cancer Center, 2, 263-276.
6.Zhang, Y.*, Weinberg, R.A.* (2018). Epithelial-to-mesenchymal transition in cancer: complexity and opportunities. Front Med., 12(4), 361-373. (IF = 9.927, C100, ESI, F1000)
7.Zhang, Y., Alexander, P., Wang, X. -F. (2017) TGF-β family signaling in the control of cell proliferation and survival. Cold Spring Harb Perspect Biol, 9(4), a022145. (IF = 9.708, C100)
8.Zhang, Y., Wang, X. -F. (2015) A niche role for cancer exosomes in metastasis. Nat. Cell Biol., 17, 709-711. (IF = 18.699, C100)
9.Zhang, Y., Yang, P., Wang, X.-F. (2014) Microenvironmental regulation of cancer metastasis by microRNAs. Trends Cell Biol., 24, 153-160. (IF = 12.007, C100)
10.Zhang, Y.#, Yang, P.#, Sun, T., Li, D., Xu, X., Rui, Y., Li, C., Chong, M., Ibrahim, T., Mercatali, L., Amadori, D., Lu, X., Xie, D., Li, Q.-J., Wang, X.-F. (2013) Mir-126 and mir-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat. Cell Biol., 15, 284-294. (IF = 20.058, C100)