張沖,國家癌癥中心/中國醫學科學院腫瘤醫院分子腫瘤學全國重點實驗室研究員,博士研究生導師,助理教授。第一(含共同)作者的研究成果在《Nature》《Cancer Cell》等雜志發表,入選ESI Top1%高被引論文、細胞出報社2019中國年度論文。主持國家自然科學基金項目、醫科院創新工程人才養募基金項目,參與國家重點研發計劃等項目。
     院校引進人才,2025年加入院校。2021年至2025年于北京大學生物醫學前沿創新中心(BIOPIC)任博雅博士后。
張沖研究組致力于運用人工智能與生物信息學分析方法,結合細胞生物學實驗方法,研究腫瘤癌前、發生發展、轉移復發等全周期中的基因組分子特征與演化模式,挖掘腫瘤發生發展過程中的規律,解決診斷、治療腫瘤過程中的難題,以期實現腫瘤的精準診療。研究方向包括:
1)腫瘤的基因組及微環境
2)運用克隆演化分析方法研究腫瘤的演進過程
3)ecDNA在腫瘤發生發展及耐藥中的影響及作用
1. Chen Lei#*, Zhang Chong#, Xue Ruidong#, Liu Mo#, Bai Jian, Bao Jinxia, Wang Yin, Jiang Nanhai, Li Zhixuan, Wang Wenwen, Wang Ruiru, Zheng Bo, Yang Airong, Hu Ji, Liu Ke, Shen Siyun, Zhang Yangqianwen, Bai Mixue, Wang Yan, Zhu Yanjing, Yang Shuai, Gao Qiang, Gu Jin, Gao Dong, Wang Xin Wei, Nakagawa Hidewaki, Zhang Ning, Wu Lin*, Rozen Steven George*, Bai Fan*, Wang Hongyang*. Deep whole-genome analysis of 494 hepatocellular carcinomas. Nature, 2024 Feb 14; 627(8004): 586–593. (IF = 50.5, ESI)
2. Xiang Xiao#, Liu Ziyang#, Zhang Chong#, Li Zhao#, Gao Jie, Zhang Changkun, Cao Qi, Cheng Jinghui, Liu Hengkang, Chen Dingbao, Cheng Qian, Zhang Ning, Xue Ruidong*, Bai Fan*, Zhu Jiye*. IDH mutation subgroup status shapes intratumor heterogeneity and the tumor microenvironment in intrahepatic cholangiocarcinoma. Adv. Sci., 2021 Jul 11; 8(17): 2101230. (IF=16.806)
3. Zhang Chong#, Zhang Lin#, Xu Tianlei#, Xue Ruidong#, Yu Liang#, Zhu Yuelu, Wu Yunlong, Zhang Qingqing, Li Dongdong, Shen Shuohao, Tan Dongfeng, Bai Fan*, Zhang Haizeng*. Mapping the spreading routes of lymphatic metastases in human colorectal cancer. Nat. Commun., 2020 Apr 24; 11(1): 1993. (IF=12.121)
4. Xue Ruidong#, Chen Lu#, Zhang Chong#, Fujita Masashi#, Li Ruoyan, Yan Shu-Mei, Ong Choon Kiat, Liao Xiwen, Gao Qiang, Sasagawa Shota, Li Yanmeng, Wang Jincheng, Guo Hua, Huang Qi-Tao, Zhong Qian, Tan Jing, Qi Lisha, Gong Wenchen, Hong Zhixian, Li Meng, Zhao Jingmin, Peng Tao, Lu Yinying, Lim Kiat Hon Tony, Boot Arnoud, Ono Atushi, Chayama Kazuaki, Zhang Zemin, Rozen Steve George, Teh Bin Tean, Wang Xin Wei, Nakagawa Hidewaki*, Zeng Mu Sheng*, Bai Fan*, Zhang Ning*. Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes. Cancer Cell, 2019 May 23; 35(6): 932–947. (IF=23.916, C100)