石磊，1979年生，籍貫湖北，中國醫學科學院基礎醫學研究所教授，博士生導師。1997年考入武漢大學生命科學學院生物基地班，2001年獲得學士學位。2001年在中國協和醫科大學生化與分子生物學專業攻讀博士學位。2007年進入耶魯大學細胞生物學系進行博士后訓練，主要研究囊泡融合的分子機制。2014年加入中國醫學科學院基礎醫學研究所工作，獲聘協和學者特聘教授。

實驗室主要研究病毒復制機制及與宿主細胞的相互作用，包括膜蛋白、蛋白質機器的功能與作用機制，病毒影響或重塑宿主細胞器結構的動態過程和分子機制，抗病毒靶點發現和抑制劑篩選等。

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1. Yali Ci#, ZhongYu Liu, NaNa Zhang, Yuqiang Niu, Yang Yang, Caimin Xu, Wei Yang*, ChengFeng Qin*, and Lei Shi*. Zika NS1–induced ER remodeling is essential for viral replication. J. Cell Biol. 2020, 219 (2): e201903062. (IF=9.4)

2. Huaipeng Xing#, Shan Xu#, Fangfei Jia#, Yang Yang, Caimin Xu, Chengfeng Qin*, Lei Shi*. Zika NS2B is a crucial factor recruiting NS3 to the ER and activating its protease activity. Virus Research.  275 (2020) 197793. (IF=6.2)

3. Shan Xu#, Yali Ci#, Leijie Wang#, Yang Yang, Leiliang Zhang, Caimin Xu, Chengfeng Qin and Lei Shi*. Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase. Nucleic Acids Research. 2019, Vol. 47, No. 16 8693–8707. (IF=19.0)

4. Yali Ci#, Yang Yang, Caimin Xu*, Lei Shi*. Vesicular stomatitis virus G protein transmembrane region is crucial for the hemi-fusion to full fusion transition. Sci Rep. 2018 Jul 13;8(1):10669. (IF=4.9)

5. Ci Y#, Shi K, An J, Yang Y, Hui K, Wu P, Shi L*, Xu C*. ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells. Cell Death Dis. 2014 Nov 27;5:e1542. (IF=9.6)

6. Shi L#, Kevin Howan#, Qingtao Shen, Yong Jian Wang, James E. Rothman, Frédéric Pincet*. Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Nature Protocols, 2013 Apr 18;8(5):935-48. (IF=17.0)

7. Shi L#, Shen QT, Alexander Kiel, Wang J, Wang HW, Melia TJ, Rothman JE*, Frédéric Pincet*. SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open. Science, 2012 Mar 16, 355:1355-1359. (IF=63, C100, F1000)

8. Li W#, Shi L#, You Y, Gong Y, Yin B, Yuan J, Peng X*. Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons. BMC Biol. 2010 Jun 18;8:86. (IF=7.3)

9. Shi L#, Yue J#, You Y, Yin B, Gong Y, Xu C, Qiang B, Yuan J, Liu Y*, Peng X*. Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation.  Cell Signal. 2006 Nov;18(11):1995-2003. (IF=4.8)