彭宗根，1975年生，中國醫學科學院醫藥生物技術研究所研究員，博士生導師。1994年考入南昌大學微生物學專業，1998年獲得學士學位。1998年在福建醫科大學病原生物學專業攻讀碩士學位，從事抗病毒性肝炎基礎研究。2001年在中國協和醫科大學微生物與生化專業攻讀博士學位，從事抗病毒藥物研究。2004年留所工作至今。2010年聘為副研究員，2013年聘為研究員。

抗病毒、抗肝炎藥物藥理學。以宿主因子為靶的抗病毒、抗非酒精性脂肪性肝炎藥物的研發。

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1. Wang Y#, Li J#, Tan J, Yang B, Quan Y, Peng Z*, Li Y*, Li Z. Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl) benzonitrile Derivatives as HCV Entry Inhibitors. J Med Chem. 2022, 65(3):2107-2121. (IF=8.039)

2. Wang M, Li J, Li H, Dong, B, Jiang, J, Liu, N, Tan, J, Wang, X, Lei, L, Li, H, Sun, H, Tang, M, Wang, H, Yan, H, Li, Y, Jiang, J, Peng, Z*. Down-regulating the high level of 17-beta-hydroxysteroid dehydrogenase 13 plays a therapeutic role for non-alcoholic fatty liver disease. Int J Mol Sci, 2022, 23(10): 5544. (IF= 6.208)

3. Li H#, Liu NN#, Li JR, Dong B, Wang MX, Tan JL, Wang XK, Jiang J, Lei L, Li HY, Sun H, Jiang JD* and Peng ZG*. Combined Use of Bicyclol and Berberine Alleviates Mouse Nonalcoholic Fatty Liver Disease. Front Pharmacol. 2022, 13:843872. (IF=5.988)

4. Zou LL, Li JR, Li H, Tan JL, Wang MX, Liu NN, Gao RM, Yan HY, Wang XK, Dong B, Li YH, Peng ZG*. TGF-β isoforms inhibit hepatitis C virus propagation in transforming growth factor beta/SMAD protein signalling pathway dependent and independent manners. J Cell Mol Med. 2021, 25(7):3498-3510. (IF=5.295)

5. Jiang X#, Tan J#, Wang Y, Chen J, Li J, Jiang Z, Quan Y, Jin J, Li Y, Cen S, Li Y*, Peng Z*, Li Z*. 2-((4-Arylpiperazin-1-yl)methyl)

benzonitrile Derivatives as Orally Available Inhibitors of Hepatitis C Virus with a Novel Mechanism of Action. J Med Chem. 2020, 63(11):5972-5989. (IF=7.446)

6. Huang MH#, Li H#, Xue R, Li JR, Wang LH, ChengJJ, Wu ZY, Li WJ, Chen JH, Lv XQ, Li Q, Lan P, Zhao LM, Yang YF*, Peng ZG*, Jiang JD*. Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication. Acta Pharmaceutica Sinica B. 2019, 9(4):769-781. (IF=7.097)

7. Li H, Li JR, Huang MH, Chen JH, Lv XQ, Zou LL, Tan JL, Dong B, Peng ZG*, Jiang JD* . Bicyclol attenuates liver inflammation induced by infection of hepatitis C virus via repressing ROS-mediated activation of MAPKs/NF-κB signaling pathway. Front. Pharmacol. 2018, 9:1438. (IF=3.845, F1000)

8. Cheng JJ, Li JR, Huang MH, Ma LL, Wu ZY, Jiang CC, Li WJ, Li YH, Han YX, Li H, Chen JH, Wang YX, Song DQ, Peng ZG*, Jiang JD*. CD36 is a co-receptor for hepatitis C virus E1 protein attachment. Sci Rep. 2016, 6:21808. (IF=4.259)

9. Peng ZG#, Zhao ZY#, Li YP#, Wang YP, Hao LH, Fan B, Li YH, Wang YM, Shan YQ, Han YX, Li JR, You XF, Li ZR*, Jiang JD*. Host apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-Like 3G is an innate defensive factor and drug target against hepatitis C virus. Hepatology, 2011, 53(4): 1080-1089. (IF=12.003)

10. Peng ZG#, Fan B#, Du NN#, Wang YP, Gao LM, Li YH, Li YH, Liu F, You XF, Han YX, Zhao ZY, Cen S, Li JR, Song DQ*, Jiang JD*. Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA. Hepatology, 2010, 52(3): 845-53. (IF=11.665)